Scientists have explained the connection between coffee consumption and migraines

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According to the study, causal -there is no causal relationship between perceived coffee consumption and migraine risk.

Heng Chen of Zhejiang University in Hangzhou, China, and colleagues examined the causal relationship between coffee consumption and migraine using a two-sample Mendelian randomization (MR) analysis.

Nine genome-wide single-nucleotide polymorphisms associated with coffee consumption were obtained from a genome-wide association study (GWAS) of 375,000 individuals from the UK biobank.

Using the largest migraine GWAS available, including 59,000 cases and 316,000 control subjects, pooled data were obtained for any migraine and its subtypes (migraine with aura and migraine without aura) . Fixed-effect weighted inverse variance was used as the primary method for pooling MR estimates.

As a result, the researchers found no causal relationship between a genetically predicted 50% increase in coffee consumption and the risk of any migraine . Similar results were obtained in sensitivity analyses.

“The actual study did not find a causal effect of genetic increases in coffee consumption on any type of migraine, and the results are consistent with sensitivity analyses,” the authors emphasize.

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