Became clear why cancer medicines are failed

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Scientists have found out why many promising drugs from tumors do not pass from tumors Further stages of clinical studies. It turns out that they can have the necessary influence, but quite differently the algorithm.

often people ask why cancer medicines are so madly expensive. One of the reasons is the fact that almost 85% of drugs that go through clinical studies do not enter the market. And on various kinds of scientific work on their creation, pharmaceutical companies consume tens and hundreds of millions of dollars. And now, scientists from the United States have found that one of the reasons for the failures of most promising cancer drugs is that they do not actually fall for their original molecular goals. This conclusion was made after the study of the mechanism of 10 very promising cancer drugs, which were originally created for attack 1 of 6 proteins.

studied that these drugs were actually destroying cancer cells, but not at all at the expense Blocking proteins. And since the initially stated mechanism was not demonstrated, these drugs did not go through the stage of clinical trials, although many patients could help. Possessing this information, in the future, scientists can improve the process of developing medicines and evidence of their effectiveness that will bring so much expected to many personalized medicine.

observations have shown that drugs killed cancer cell influence. In other words, these drugs can be effective against a certain protein in some isolated laboratory, but when they enter the living human body and affect malignant cells, they begin to behave differently.