Scientists have named a probiotic that is really effective in intestinal diseases

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Intestinal epithelial dense compounds (TJ) act as a functional and structural barrier against harmful antigens that contribute to intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory bowel conditions. A defective intestinal barrier known as “leaky gut” plays an important role in exacerbating and perpetuating intestinal inflammation.

A new study published in the American Journal of Pathology shows that a probiotic strain of Lactobacillus acidophilus (L. acidophilus), known as LA1, can induce a rapid and sustained strengthening of this defective intestinal barrier and effectively treat intestinal inflammation while preserving and repairing the gut.< /p>

Scientists used high-throughput screening to evaluate more than 20 probiotic bacteria to determine their ability to increase gut barrier function using both a cultured model of intestinal epithelial lining cells and live mice.

The probiotic bacteria species L. acidophilus, in particular strain LA1, caused a rapid and noticeable increase in the intestinal barrier; other strains within L. acidophilin had no effect. The researchers discovered that this particular strain interacts with intestinal cells in a unique way, activating pathways that tighten the intestinal barrier, eliminating intestinal inflammation. It attaches to the surface of the intestinal epithelial membrane, interacting directly with the Toll-like receptor-2 complex, which alerts the intestine to trigger an immune response. spectrum of intestinal permeability disorders, including IBD, celiac disease, alcoholic liver disease, nonalcoholic fatty liver disease, and necrotizing enterocolitis, for the treatment of inflammation associated with leaky gut,” the authors write.

L. acidophilus is found in various brands of yogurt.