The risk of developing diabetes largely depends on the work schedule

0 < p>Scientists have discovered the relationship between metabolism and the human biological clock.

People who work in shifts are more prone than others to the risk of developing diabetes or obesity. This was the conclusion reached by researchers from the Perelman School of Medicine at the University of Pennsylvania, who saw the relationship between meals and health.

They found out that the so-called biological clock exists not only in the whole organism as a whole, but also in each cell, which requires compliance with a schedule that is comfortable for it. Violations lead to malfunctions in the body and health problems.

“The internal clock in the brain synchronizes biorhythms in peripheral tissues, and disturbances in this system lead to problems with metabolism,” explained the diabetes specialist. and metabolic diseases Mitchell Lazar, who was engaged in research.

Irregular eating can lead to diabetes and obesity, scientists have concluded, publishing the results of their research in the journal Science. They tested their theory on laboratory animals.

Lazar's team, led by Dr. Dongyin Guan, bred a group of mice in which internal clocks were disrupted in hepatocytes, the main type of liver cell that is the body's metabolic center. As a result, subjects had an increased risk of heart disease, diabetes, and stroke. This proved that the normal functioning of biorhythms in liver cells is extremely important for maintaining the normal state of the body.

As a result of the experiments, it was also proved that biorhythms are affected not only by periods of sleep and wakefulness, but also by the time of eating: nutrition mice influenced at least half of the internal clock setting factors.

According to the scientists, the obtained results should be used to optimize the changing schedule of employees in order to minimize occupational diseases. The conclusions drawn will also be useful when drawing up a treatment strategy for patients with metabolic disorders.