Vitamin D deficiency can lead to death

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Scientists from Australia have proven that vitamin D deficiency increases the risk of mortality. At the same time, even a slight increase in the level of this vitamin reduces the risk of death.

Due to the Mendeleev randomization approach, which uses genetic variants as proxy indicators for external factors affecting vitamin D levels, scientists have proven that a lack of this nutrient increases the risk of mortality.

Factors that affect vitamin D levels, such as sun exposure or food intake, were also taken into account. The study was able to analyze the relationship between vitamin D deficiency and the impact on human health, including mortality, which is impossible to achieve in randomized clinical trials due to well-understood ethical considerations.

The association between genetically predicted vitamin D levels and mortality from several major causes has been proven. A cause-and-effect relationship has been established, which is of great importance.

Unlike other types of observational studies, some methodological obstacles have been overcome.

The data from this study show the importance of a blood vitamin D threshold of 50 nanomoles per liter. They are consistent with previous observations that showed that the benefits of vitamin D supplementation are mainly observed in people with vitamin D deficiency.