What specifically causes senile dementia in men?

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Scientists have said that risk factors for the development of Alzheimer's disease affect men and women differently. Alzheimer's disease is characterized by the deterioration of cognitive abilities mainly in the elderly.

The authors from the University of Alberta studied the data of 623 elderly people collected over 44 years. In particular, they were interested in two risk factors for Alzheimer's disease — the presence of mutations in the BIN1 gene and vascular health.

It turned out that poor vascular health, namely high pulse pressure, was associated with a deterioration in episodic memory. in men and women. But even with a good pulse pressure, if there was a mutation in BIN1, the risk of the disease was high. And the presence of these two factors had a much stronger effect on men's recall.